Researchers used their network mapping technique to identify specific brain circuits underlying the response to sham surgery in Parkinson’s disease patients participating in a gene therapy trial. The expression of this network measured under blinded conditions correlated with the sham subjects’ clinical outcome; the network changes were reversed when the subjects learned of their sham treatment status. Finally, an individual subject’s network expression value measured before the treatment predicted his/her subsequent blinded response to sham treatment. This suggests that this novel image-based measure of the sham-related network can help to reduce the number of subjects assigned to sham treatment in randomized clinical trials for brain disorders by excluding those subjects who are more likely to display placebo effects under blinded conditions.
About the Author: Dr Ramesh Manocha
Dr Ramesh Manocha MBBS BSc (med) PhD is a GP, educator and researcher. His PhD was completed at the Royal Hospital for Women and focused on the scientific evaluation of meditation and the mental silence experience. Ramesh is currently a senior lecturer at the Department of Psychiatry at Sydney University and is also the founder and convenor of Generation Next, a national circuit of professional development seminars for education, health and welfare professionals.